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| Duval, David; Galinier, Richard; Mouahid, Gabriel; Toulza, Eve; Allienne, Jean Francois; Portela, Julien; Calvayrac, Christophe; Rognon, Anne; Arancibia, Nathalie; Mitta, Guillaume; Theron, Andre; Gourbal, Benjamin. |
| Background Schistosomiasis is the second-most widespread tropical parasitic disease after malaria. Various research strategies and treatment programs for achieving the objective of eradicating schistosomiasis within a decade have been recommended and supported by the World Health Organization. One of these approaches is based on the control of snail vectors in endemic areas. Previous field studies have shown that competitor or predator introduction can reduce snail numbers, but no systematic investigation has ever been conducted to identify snail microbial pathogens and evaluate their molluscicidal effects. Methodology/Principal findings In populations of Biomphalaria glabrata snails experiencing high mortalities, white nodules were visible on snail... |
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| Ano: 2015 |
URL: https://archimer.ifremer.fr/doc/00615/72716/71712.pdf |
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| Mintsa Nguema, Rodrigue; Mavoungou, Jacques F.; Ngou-milama, Krystina Mengue Me; Mamfoumbi, Modeste Mabicka; Koumba, Aubin A.; Lamine, Mariama Sani; Diarra, Abdoulaye; Asseko, Ghislaine Nkone; Mourou, Jean R.; Akotet, Marielle K. Bouyou; Mone, Helene; Mouahid, Gabriel; Atsame, Julienne. |
| In order to follow the Preventive Chemotherapy (PC) for the transmission control as recommended by WHO, Gabon initiated in 2014 the mapping of Schistosomiasis and Soil Transmitted Helminthiasis (STH). Here, we report the results of the Northern and Eastern health regions, representing a third of the land area and 12% of its total population. All nine departments of the two regions were surveyed and from each, five schools were examined with 50 schoolchildren per school. The parasitological examinations were realized using the filtration method for urine and the Kato-Katz technique for stool samples. Overall 2245 schoolchildren (1116 girls and 1129 boys), mean aged 11.28 +/- 0.04 years, were examined. Combined schistosomiasis and STH affected 1270 (56.6%)... |
| Tipo: Text |
Palavras-chave: Schistosomiasis; Soil-transmitted-helminthiasis; Mapping; Preventive chemotherapy; Transmission control; Gabon; Central Africa. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00660/77212/78691.pdf |
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| Aemero, Mulugeta; Boissier, Jerome; Climent, Deborah; Mone, Helene; Mouahid, Gabriel; Berhe, Nega; Erko, Berhanu. |
| Background: Human intestinal schistosomiasis caused by Schistosoma mansoni and urinary schistosomiasis caused by Schistosoma haematobium are endemic in Ethiopia. Although schistosomes look morphologically uniform, there is variation in infectivity, egg productivity and virulence due to variation in their genetic make. Knowing the genetic diversity and population structure of S. mansoni isolates will enable to understand and consider the possible variability in terms of infectivity, egg productivity and virulence. Methods: Between 2010 and 2011, genetic diversity and population structure of Schistosoma mansoni isolates from four endemic areas of Ethiopia was assessed using previously published 11 polymorphic microsatellite loci. Miracidia were hatched from... |
| Tipo: Text |
Palavras-chave: Schistosoma mansoni; Microsatellite; Genetic diversity; Population structure; Ethiopia. |
| Ano: 2015 |
URL: https://archimer.ifremer.fr/doc/00302/41369/71868.pdf |
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| Chevalier, Frederic D.; Le Clec'H, Winka; Mcdew-white, Marina; Menon, Vinay; Guzman, Meghan A.; Holloway, Stephen P.; Cao, Xiaohang; Taylor, Alexander B.; Kinung'Hi, Safari; Gouvras, Anouk N.; Webster, Bonnie L.; Webster, Joanne P.; Emery, Aidan M.; Rollinson, David; Garba Djirmay, Amadou; Al Mashikhi, Khalid M.; Al Yafae, Salem; Idris, Mohamed A.; Mone, Helene; Mouahid, Gabriel; Hart, P. John; Loverde, Philip T.; Anderson, Timothy J. C.. |
| Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that alleles conferring resistance to oxamniquine (OXA), an antischistosomal drug, are widespread in natural parasite populations under minimal drug pressure and predate OXA deployment. OXA has been used since the 1970s to treat Schistosoma mansoni infections in the New World where S. mansoni established during the slave trade. Recessive loss-of-function mutations within a parasite sulfotransferase (SmSULT-OR) underlie resistance, and several verified resistance... |
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| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00659/77118/78534.pdf |
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| Aliaga, Benoit; Bulla, Ingo; Mouahid, Gabriel; Duval, David; Grunau, Christoph. |
| provides just a set of environment dependent instructions, or whether it is integral part of an inheritance system. We argued that in the latter case the epigenetic code should share the universality quality of the genetic code. We focused on DNA methylation. Since availability of DNA methylation data is biased towards model organisms we developed a method that uses kernel density estimations of CpG observed/expected ratios to infer DNA methylation types in any genome. We show here that our method allows for robust prediction of mosaic and full gene body methylation with a PPV of 1 and 0.87, respectively. We used this prediction to complement experimental data, and applied hierarchical clustering to identify methylation types in similar to 150 eucaryotic... |
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| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00479/59040/61671.pdf |
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